Authors: Carolina Serena, Monica Millan, Miriam Ejarque, Alfonso Saera-Vila, Elsa Maymó-Masip, Catalina Núñez-Roa, Diandra Monfort-Ferré, Margarida Terrón-Puig, Michelle Bautista, Margarita Menacho, Marc Martí, Eloy Espin, Joan Vendrell, Sonia Fernández-Veledo
Institutions:
- Institut d´Investigació Sanitària Pere Virgili, Hospital Universitari Joan XXIII, Dr Mallafré Guasch, 4, 43007, Tarragona, Spain
- CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28014, Madrid, Spain
- Colorectal Surgery Unit, Hospital Universitari Joan XXIII, 43007, Tarragona, Spain
- Colorectal Surgery Unit, Hospital Universitari La Fe, Valencia, Spain
- Digestive Unit, Hospital Universitari Joan XXIII, 43007, Tarragona, Spain
- Colorectal Surgery Unit, General Surgery Service, Hospital Valle de Hebron, Universitat Autonoma de Barcelona, 08035, Barcelona, Spain
- Universitat Rovira i Virgili, Tarragona, Spain
Publication: Springer Link
Date: April, 2020
Link: Adipose stem cells from patients with Crohn’s disease show a distinctive DNA methylation pattern
Abstract:
Crohn’s disease (CD) is characterized by persistent inflammation and ulceration of the small or large bowel, and expansion of mesenteric adipose tissue, termed creeping fat (CF). We previously demonstrated that human adipose-derived stem cells (hASCs) from CF of patients with CD exhibit dysfunctional phenotypes, including a pro-inflammatory profile, high phagocytic capacity, and weak immunosuppressive properties. Importantly, these phenotypes persist in patients in remission and are found in all adipose depots explored including subcutaneous fat. We hypothesized that changes in hASCs are a consequence of epigenetic modifications.
