{"id":8957,"date":"2022-02-17T09:22:37","date_gmt":"2022-02-17T09:22:37","guid":{"rendered":"https:\/\/dev.sequentiabiotech.com\/publication\/a-genetic-compensatory-mechanism-regulated-by-jun-and-mef2d-modulates-the-expression-of-distinct-class-iia-hdacs-to-ensure-peripheral-nerve-myelination-and-repair\/"},"modified":"2026-02-25T12:05:04","modified_gmt":"2026-02-25T12:05:04","slug":"a-genetic-compensatory-mechanism-regulated-by-jun-and-mef2d-modulates-the-expression-of-distinct-class-iia-hdacs-to-ensure-peripheral-nerve-myelination-and-repair","status":"publish","type":"publication","link":"https:\/\/www.sequentiabiotech.com\/it\/publication\/a-genetic-compensatory-mechanism-regulated-by-jun-and-mef2d-modulates-the-expression-of-distinct-class-iia-hdacs-to-ensure-peripheral-nerve-myelination-and-repair\/","title":{"rendered":"A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair"},"content":{"rendered":"<p><strong>Authors:<\/strong> Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rinc\u00f3n, Enrique Velasco, Juana Gallar, Peter Arthur-Farraj, Jose A Gomez-Sanchez, Hugo Cabedo<\/p>\n<p><strong>Institutions:<\/strong><\/p>\n<ul>\n<li class=\"content-header__institution_list_item\"><span class=\"content-header__institution\">Instituto de Neurociencias de Alicante UMH-CSIC, Spain<\/span><\/li>\n<li class=\"content-header__institution_list_item\"><span class=\"content-header__institution\">Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL), Spain<\/span><\/li>\n<li class=\"content-header__institution_list_item\"><span class=\"content-header__institution\">The European University of Brain and Technology-NeurotechEU, Spain<\/span><\/li>\n<li class=\"content-header__institution_list_item\"><span class=\"content-header__institution\">RICORS en enfermedades inflamatorias, Spain<\/span><\/li>\n<li class=\"content-header__institution_list_item content-header__institution_list_item--last\"><span class=\"content-header__institution\">John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, United Kingdom<\/span><\/li>\n<\/ul>\n<p><strong>Publication:<\/strong> e<em>Life Sciences<\/em><\/p>\n<p><strong>Date:<\/strong> January 2022<\/p>\n<p><strong>Full paper<\/strong>: <a href=\"https:\/\/elifesciences.org\/articles\/72917#content\">A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair<\/a><\/p>\n<p><strong>Abstract:<\/strong><\/p>\n<p>The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express\u00a0<i>Hdac4<\/i>,\u00a0<i>5<\/i>, and\u00a0<i>7<\/i>\u00a0but not\u00a0<i>Hdac9<\/i>. Here, we show that a transcription factor regulated genetic compensatory mechanism within this family of proteins, blocks negative regulators of myelination ensuring peripheral nerve developmental myelination and remyelination after injury. Thus, when\u00a0<i>Hdac4<\/i>\u00a0and\u00a0<i>5<\/i>\u00a0are knocked-out from Schwann cells in mice, a JUN-dependent mechanism induces the compensatory overexpression of\u00a0<i>Hdac7<\/i>\u00a0permitting, although with a delay, the formation of the myelin sheath. When\u00a0<i>Hdac4<\/i>,\u00a0<i>5<\/i>, and\u00a0<i>7<\/i>\u00a0are simultaneously removed, the myocyte-specific enhancer-factor d (MEF2D) binds to the promoter and induces the de novo expression of\u00a0<i>Hdac9<\/i>, and although several melanocytic lineage genes are misexpressed and Remak bundle structure is disrupted, myelination proceeds after a long delay. Thus, our data unveil a finely tuned compensatory mechanism within the class IIa\u00a0<i>Hdac<\/i>\u00a0family, coordinated by distinct transcription factors, that guarantees the ability of Schwann cells to myelinate during development and remyelinate after nerve injury.<\/p>\n","protected":false},"featured_media":9495,"parent":0,"template":"","meta":{"_acf_changed":false},"omics-area":[41,40],"application-field":[35,37],"solution":[46],"publication-type":[50],"class_list":["post-8957","publication","type-publication","status-publish","has-post-thumbnail","hentry","omics-area-epigenomics","omics-area-transcriptomics","application-field-basic-research","application-field-health","solution-air","publication-type-citations"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair - Sequentia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sequentiabiotech.com\/it\/publication\/a-genetic-compensatory-mechanism-regulated-by-jun-and-mef2d-modulates-the-expression-of-distinct-class-iia-hdacs-to-ensure-peripheral-nerve-myelination-and-repair\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair - Sequentia\" \/>\n<meta property=\"og:description\" content=\"Authors: Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rinc\u00f3n, Enrique Velasco, Juana Gallar, Peter Arthur-Farraj, Jose A Gomez-Sanchez, Hugo Cabedo Institutions: Instituto de Neurociencias de Alicante UMH-CSIC, Spain Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL), Spain The European University of Brain and Technology-NeurotechEU, Spain RICORS en enfermedades inflamatorias, Spain John Van Geest Centre [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sequentiabiotech.com\/it\/publication\/a-genetic-compensatory-mechanism-regulated-by-jun-and-mef2d-modulates-the-expression-of-distinct-class-iia-hdacs-to-ensure-peripheral-nerve-myelination-and-repair\/\" \/>\n<meta property=\"og:site_name\" content=\"Sequentia\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T12:05:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sequentiabiotech.com\/wp-content\/uploads\/2025\/06\/44-e1770713850300.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1080\" \/>\n\t<meta property=\"og:image:height\" content=\"605\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sequentiabiotech.com\\\/it\\\/publication\\\/a-genetic-compensatory-mechanism-regulated-by-jun-and-mef2d-modulates-the-expression-of-distinct-class-iia-hdacs-to-ensure-peripheral-nerve-myelination-and-repair\\\/\",\"url\":\"https:\\\/\\\/www.sequentiabiotech.com\\\/it\\\/publication\\\/a-genetic-compensatory-mechanism-regulated-by-jun-and-mef2d-modulates-the-expression-of-distinct-class-iia-hdacs-to-ensure-peripheral-nerve-myelination-and-repair\\\/\",\"name\":\"A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair - 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