{"id":9027,"date":"2023-02-02T07:55:52","date_gmt":"2023-02-02T07:55:52","guid":{"rendered":"https:\/\/dev.sequentiabiotech.com\/publication\/3d-chromatin-remodelling-in-the-germ-line-modulates-genome-evolutionary-plasticity-2\/"},"modified":"2026-02-25T12:04:57","modified_gmt":"2026-02-25T12:04:57","slug":"3d-chromatin-remodelling-in-the-germ-line-modulates-genome-evolutionary-plasticity-2","status":"publish","type":"publication","link":"https:\/\/www.sequentiabiotech.com\/it\/publication\/3d-chromatin-remodelling-in-the-germ-line-modulates-genome-evolutionary-plasticity-2\/","title":{"rendered":"3D chromatin remodelling in the germ line modulates genome evolutionary plasticity"},"content":{"rendered":"<p><strong>Authors:<\/strong> Luc\u00eda \u00c1lvarez-Gonz\u00e1lez, Frances Burden, Dadakhalandar Doddamani, Roberto Malinverni, Emma Leach, Cristina Mar\u00edn-Garc\u00eda, Laia Mar\u00edn-Gual, Albert Gubern, Covadonga Vara, Andreu Paytuv\u00ed-Gallart, Marcus Buschbeck, Peter J. I. Ellis, Marta Farr\u00e9, Aurora Ruiz-Herrera<\/p>\n<p><strong>Institutions:<\/strong><\/p>\n<ul>\n<li>Departament de Biologia Cel\u00b7lular, Fisiologia i Immunologia, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain<\/li>\n<li>Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain<\/li>\n<li>School of Bioscience, University of Kent, Canterbury, UK<\/li>\n<li>Cancer and Leukemia Epigenetics and Biology Program, Josep Carreras Leukaemia Research Institute (IJC), Campus ICO-GTP-UAB, Badalona, Spain<\/li>\n<li>Sequentia Biotech, Barcelona, Spain<\/li>\n<li>Program for Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), Badalona, Spain<\/li>\n<\/ul>\n<p><strong>Publication:<\/strong> <em>Nature Communications<\/em><\/p>\n<p><strong>Date:<\/strong> May, 2022<\/p>\n<p><strong>Link:<\/strong> <a href=\"https:\/\/www.nature.com\/articles\/s41467-022-30296-6\">3D chromatin remodelling in the germ line modulates genome evolutionary plasticity<\/a><\/p>\n<p><strong>Abstract:<\/strong><\/p>\n<p>Chromosome folding has profound impacts on gene regulation, whose evolutionary consequences are far from being understood. Here we explore the relationship between 3D chromatin remodelling in mouse germ cells and evolutionary changes in genome structure. Using a comprehensive integrative computational analysis, we (i) reconstruct seven ancestral rodent genomes analysing whole-genome sequences of 14 species representatives of the major phylogroups, (ii) detect lineage-specific chromosome rearrangements and (iii) identify the dynamics of the structural and epigenetic properties of evolutionary breakpoint regions (EBRs) throughout mouse spermatogenesis. Our results show that EBRs are devoid of programmed meiotic DNA double-strand breaks (DSBs) and meiotic cohesins in primary spermatocytes, but are associated in post-meiotic cells with sites of DNA damage and functional long-range interaction regions that recapitulate ancestral chromosomal configurations. Overall, we propose a model that integrates evolutionary genome reshuffling with DNA damage response mechanisms and the dynamic spatial genome organisation of germ cells.<\/p>\n","protected":false},"featured_media":9495,"parent":0,"template":"","meta":{"_acf_changed":false},"omics-area":[40],"application-field":[35,37],"solution":[46],"publication-type":[49],"class_list":["post-9027","publication","type-publication","status-publish","has-post-thumbnail","hentry","omics-area-transcriptomics","application-field-basic-research","application-field-health","solution-air","publication-type-peer-reviewed-articles"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>3D chromatin remodelling in the germ line modulates genome evolutionary plasticity - Sequentia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sequentiabiotech.com\/it\/publication\/3d-chromatin-remodelling-in-the-germ-line-modulates-genome-evolutionary-plasticity-2\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"3D chromatin remodelling in the germ line modulates genome evolutionary plasticity - Sequentia\" \/>\n<meta property=\"og:description\" content=\"Authors: Luc\u00eda \u00c1lvarez-Gonz\u00e1lez, Frances Burden, Dadakhalandar Doddamani, Roberto Malinverni, Emma Leach, Cristina Mar\u00edn-Garc\u00eda, Laia Mar\u00edn-Gual, Albert Gubern, Covadonga Vara, Andreu Paytuv\u00ed-Gallart, Marcus Buschbeck, Peter J. 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Ellis, Marta Farr\u00e9, Aurora Ruiz-Herrera Institutions: Departament de Biologia Cel\u00b7lular, Fisiologia i Immunologia, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain Genome Integrity and Instability Group, Institut de Biotecnologia [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sequentiabiotech.com\/it\/publication\/3d-chromatin-remodelling-in-the-germ-line-modulates-genome-evolutionary-plasticity-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Sequentia\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T12:04:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sequentiabiotech.com\/wp-content\/uploads\/2025\/06\/44-e1770713850300.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1080\" \/>\n\t<meta property=\"og:image:height\" content=\"605\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sequentiabiotech.com\\\/it\\\/publication\\\/3d-chromatin-remodelling-in-the-germ-line-modulates-genome-evolutionary-plasticity-2\\\/\",\"url\":\"https:\\\/\\\/www.sequentiabiotech.com\\\/it\\\/publication\\\/3d-chromatin-remodelling-in-the-germ-line-modulates-genome-evolutionary-plasticity-2\\\/\",\"name\":\"3D chromatin remodelling in the germ line modulates genome evolutionary plasticity - 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Ellis, Marta Farr\u00e9, Aurora Ruiz-Herrera Institutions: Departament de Biologia Cel\u00b7lular, Fisiologia i Immunologia, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain Genome Integrity and Instability Group, Institut de Biotecnologia [&hellip;]","og_url":"https:\/\/www.sequentiabiotech.com\/it\/publication\/3d-chromatin-remodelling-in-the-germ-line-modulates-genome-evolutionary-plasticity-2\/","og_site_name":"Sequentia","article_modified_time":"2026-02-25T12:04:57+00:00","og_image":[{"width":1080,"height":605,"url":"https:\/\/www.sequentiabiotech.com\/wp-content\/uploads\/2025\/06\/44-e1770713850300.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Tempo di lettura stimato":"2 minuti"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.sequentiabiotech.com\/it\/publication\/3d-chromatin-remodelling-in-the-germ-line-modulates-genome-evolutionary-plasticity-2\/","url":"https:\/\/www.sequentiabiotech.com\/it\/publication\/3d-chromatin-remodelling-in-the-germ-line-modulates-genome-evolutionary-plasticity-2\/","name":"3D chromatin remodelling in the germ line modulates genome evolutionary plasticity - 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