{"id":9061,"date":"2024-02-28T11:40:59","date_gmt":"2024-02-28T11:40:59","guid":{"rendered":"https:\/\/dev.sequentiabiotech.com\/publication\/hematopoietic-stem-cell-navigation\/"},"modified":"2026-02-25T12:09:23","modified_gmt":"2026-02-25T12:09:23","slug":"hematopoietic-stem-cell-navigation","status":"publish","type":"publication","link":"https:\/\/www.sequentiabiotech.com\/it\/publication\/hematopoietic-stem-cell-navigation\/","title":{"rendered":"\u03b11,3-fucosylation treatment improves cord blood CD34 negative hematopoietic stem cell navigation"},"content":{"rendered":"<p>Authors: Asma S. Al-Amoodi, Jing Kai, Yanyan Li, Jana S. Malki, Abdullah Alghamdi, Arwa Al-Ghuneim, Alfonso Saera-Vila, Satoshi Habuchi &amp; Jasmeen S. Merzaban<\/p>\n<p>Publication: Cell<\/p>\n<p>Published: January, 2024<\/p>\n<p>Link: https:\/\/doi.org\/10.1016\/j.isci.2024.108882<\/p>\n<p>Abstract:<\/p>\n<p>For almost two decades, clinicians have overlooked the diagnostic potential of CD34neg hematopoietic stem cells because of their limited homing capacity relative to CD34posHSCs when injected intravenously. This has contributed to the lack of appeal of using umbilical cord blood in HSC transplantation because its stem cell count is lower than bone marrow. The present study reveals that the homing and engraftment of CD34negHSCs can be improved by adding the Sialyl Lewis X molecule via \u03b11,3-fucosylation. This unlocks the potential for using this more primitive stem cell to treat blood disorders because our findings show CD34negHSCs have the capacity to regenerate cells in the bone marrow of mice for several months. Furthermore, our RNA sequencing analysis revealed that CD34negHSCs have unique adhesion pathways, downregulated in CD34posHSCs, that facilitate interaction with the bone marrow niche. Our findings suggest that CD34neg cells will best thrive when the HSC resides in its microenvironment.<\/p>\n","protected":false},"featured_media":9495,"parent":0,"template":"","meta":{"_acf_changed":false},"omics-area":[40],"application-field":[35,37],"solution":[],"publication-type":[49],"class_list":["post-9061","publication","type-publication","status-publish","has-post-thumbnail","hentry","omics-area-transcriptomics","application-field-basic-research","application-field-health","publication-type-peer-reviewed-articles"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u03b11,3-fucosylation treatment improves cord blood CD34 negative hematopoietic stem cell navigation - Sequentia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sequentiabiotech.com\/it\/publication\/hematopoietic-stem-cell-navigation\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u03b11,3-fucosylation treatment improves cord blood CD34 negative hematopoietic stem cell navigation - Sequentia\" \/>\n<meta property=\"og:description\" content=\"Authors: Asma S. Al-Amoodi, Jing Kai, Yanyan Li, Jana S. Malki, Abdullah Alghamdi, Arwa Al-Ghuneim, Alfonso Saera-Vila, Satoshi Habuchi &amp; Jasmeen S. Merzaban Publication: Cell Published: January, 2024 Link: https:\/\/doi.org\/10.1016\/j.isci.2024.108882 Abstract: For almost two decades, clinicians have overlooked the diagnostic potential of CD34neg hematopoietic stem cells because of their limited homing capacity relative to CD34posHSCs [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sequentiabiotech.com\/it\/publication\/hematopoietic-stem-cell-navigation\/\" \/>\n<meta property=\"og:site_name\" content=\"Sequentia\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T12:09:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sequentiabiotech.com\/wp-content\/uploads\/2025\/06\/44-e1770713850300.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1080\" \/>\n\t<meta property=\"og:image:height\" content=\"605\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.sequentiabiotech.com\\\/it\\\/publication\\\/hematopoietic-stem-cell-navigation\\\/\",\"url\":\"https:\\\/\\\/www.sequentiabiotech.com\\\/it\\\/publication\\\/hematopoietic-stem-cell-navigation\\\/\",\"name\":\"\u03b11,3-fucosylation treatment improves cord blood CD34 negative hematopoietic stem cell navigation - 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Merzaban Publication: Cell Published: January, 2024 Link: https:\/\/doi.org\/10.1016\/j.isci.2024.108882 Abstract: For almost two decades, clinicians have overlooked the diagnostic potential of CD34neg hematopoietic stem cells because of their limited homing capacity relative to CD34posHSCs [&hellip;]","og_url":"https:\/\/www.sequentiabiotech.com\/it\/publication\/hematopoietic-stem-cell-navigation\/","og_site_name":"Sequentia","article_modified_time":"2026-02-25T12:09:23+00:00","og_image":[{"width":1080,"height":605,"url":"https:\/\/www.sequentiabiotech.com\/wp-content\/uploads\/2025\/06\/44-e1770713850300.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Tempo di lettura stimato":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.sequentiabiotech.com\/it\/publication\/hematopoietic-stem-cell-navigation\/","url":"https:\/\/www.sequentiabiotech.com\/it\/publication\/hematopoietic-stem-cell-navigation\/","name":"\u03b11,3-fucosylation treatment improves cord blood CD34 negative hematopoietic stem cell navigation - 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