Authors: F. Contaldi, F. Capuano, A. Fulgione, R. Aiese Cigliano, W. Sanseverino, D. Iannelli, C. Medaglia R. Capparelli
Institutions:
- Department of Agriculture, University of Naples “Federico II”, Portici, 80055, Italy
- Department of Food Microbiology, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, 80055, Italy
- Sequentia Biotech, Barcelona, Spain
- Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel
Publication: Scientific Reports
Date: August, 2017
Full paper: The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible
Abstract:
There is epidemiological evidence that H. pylori might predispose to Alzheimer’s disease. To understand the cellular processes potentially linking such unrelated events, we incubated the human gastric cells MNK-28 with the H. pylori peptide Hp(2-20). We then monitored the activated genes by global gene expression. The peptide modulated 77 genes, of which 65 are listed in the AlzBase database and include the hallmarks of Alzheimer’s disease: APP, APOE, PSEN1, and PSEN2. A large fraction of modulated genes (30 out of 77) belong to the inflammation pathway. Remarkably, the pathways dis-regulated in Alzheimer’s and Leasch-Nyhan diseases result dis-regulated also in this study. The unsuspected links between such different diseases – though still awaiting formal validation – suggest new directions for the study of neurological diseases.
