Authors: F. ContaldiF. CapuanoA. FulgioneR. Aiese CiglianoW. SanseverinoD. IannelliC. Medaglia R. Capparelli


  • Department of Agriculture, University of Naples “Federico II”, Portici, 80055, Italy
  • Department of Food Microbiology, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, 80055, Italy
  • Sequentia Biotech, Barcelona, Spain
  • Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel

Publication: Scientific Reports

Date: August, 2017

Full paper: The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible


There is epidemiological evidence that H. pylori might predispose to Alzheimer’s disease. To understand the cellular processes potentially linking such unrelated events, we incubated the human gastric cells MNK-28 with the H. pylori peptide Hp(2-20). We then monitored the activated genes by global gene expression. The peptide modulated 77 genes, of which 65 are listed in the AlzBase database and include the hallmarks of Alzheimer’s disease: APP, APOE, PSEN1, and PSEN2. A large fraction of modulated genes (30 out of 77) belong to the inflammation pathway. Remarkably, the pathways dis-regulated in Alzheimer’s and Leasch-Nyhan diseases result dis-regulated also in this study. The unsuspected links between such different diseases – though still awaiting formal validation – suggest new directions for the study of neurological diseases.