Time-dependent sequestration of RVE8 by LNK proteins shapes the diurnal oscillation of anthocyanin biosynthesis

unknown-2We have been acknowledged in: 

Pérez-García, P., Ma, Y., Yanovsky, M. J., & Mas, P. (2015).

Proceedings of the National Academy of Sciences, 112(16), 5249–5253.

The circadian clock plays a crucial role controlling a wide variety of physiologic and metabolic processes in plants. However, the components and mechanisms involved in such regulation remain to be fully elucidated. Here we show that a protein complex composed of the clock components REVEILLE8/LHY-CCA1-LIKE5 (RVE8/LCL5) and the NIGHT LIGHT–INDUCIBLE AND CLOCK-REGULATED (LNK) proteins has a dual regulatory function. The complex acts as a repressor of the clock-controlled anthocyanin biosynthetic pathway at midday but it switches to an activating function in the control of evening-expressed clock genes. The interaction with LNKs impedes RVE8 binding to the promoters of the anthocyanin genes but not to the clock genes, which provides a mechanism by which LNKs antagonize RVE8 function to repress anthocyanin accumulation.



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